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Systemic application of the transient receptor potential vanilloid-type 4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

In humans, skin is a primary thermoregulatory organ, with vasodilation leading to rapid body cooling, whereas in Rodentia the tail performs an analogous function. Many thermodetection mechanisms are likely to be involved including transient receptor potential vanilloid-type 4 (TRPV4), an ion channel...

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Detalles Bibliográficos
Autores principales: O'Brien, Fiona, Staunton, Caroline A., Barrett-Jolley, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198786/
https://www.ncbi.nlm.nih.gov/pubmed/35702981
http://dx.doi.org/10.1098/rsbl.2022.0129