Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

Transforming growth factor β1 (TGF-β1) regulates a wide variety of events in adult bone marrow (BM), including quiescence of hematopoietic stem cells, via undefined mechanisms. Because megakaryocytes (MKs)/platelets are a rich source of TGF-β1, we assessed whether TGF-β1 might inhibit its own produc...

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Detalles Bibliográficos
Autores principales: Gostynska, Sandra, Venkatesan, Thamizhiniyan, Subramani, Kumar, Cortez, Brienne, Robertson, Amanda, Subrahmanian, Sandeep, Dube, Pratibha, Ahamed, Jasimuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198906/
https://www.ncbi.nlm.nih.gov/pubmed/35358295
http://dx.doi.org/10.1182/bloodadvances.2021005977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198906/
https://www.ncbi.nlm.nih.gov/pubmed/35358295
http://dx.doi.org/10.1182/bloodadvances.2021005977

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