A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

The SRC family kinase (SFK) HCK is transcriptionally upregulated and activated by mutated MYD88 (MYD88(Mut)), a key adaptor for Toll-receptor signaling. HCK activates BTK, AKT, and ERK in MYD88(Mut) lymphomas. SYK, a B-cell receptor (BCR) component, is activated in MYD88(Mut) lymphoma cells. Althoug...

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Detalles Bibliográficos
Autores principales: Munshi, Manit, Liu, Xia, Kofides, Amanda, Tsakmaklis, Nickolas, Guerrera, Maria Luisa, Hunter, Zachary R., Palomba, M. Lia, Argyropoulos, Kimon V., Patterson, Christopher J., Canning, Alexa G., Meid, Kirsten, Gustine, Joshua, Branagan, Andrew R., Flynn, Catherine A., Sarosiek, Shayna, Castillo, Jorge J., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Munshi, Nikhil C., Anderson, Kenneth C., Treon, Steven P., Yang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198919/
https://www.ncbi.nlm.nih.gov/pubmed/35255496
http://dx.doi.org/10.1182/bloodadvances.2021006147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198919/
https://www.ncbi.nlm.nih.gov/pubmed/35255496
http://dx.doi.org/10.1182/bloodadvances.2021006147

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