Identification of novel γ-globin inducers among all potential erythroid druggable targets

Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes in adult red blood cells can ameliorate many symptoms associated with the inherited β-globinop...

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Detalles Bibliográficos
Autores principales: Yu, Lei, Myers, Greggory, Schneider, Emily, Wang, Yu, Mathews, Raven, Lim, Kim Chew, Siemieniak, David, Tang, Vi, Ginsburg, David, Balbin-Cuesta, Ginette, Singh, Sharon A., Phuwakanjana, Pongpon, Jearawiriyapaisarn, Natee, Khoriaty, Rami, Engel, James Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198928/
https://www.ncbi.nlm.nih.gov/pubmed/35240686
http://dx.doi.org/10.1182/bloodadvances.2021006802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198928/
https://www.ncbi.nlm.nih.gov/pubmed/35240686
http://dx.doi.org/10.1182/bloodadvances.2021006802

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