Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency

[Image: see text] Inhibition of monoglyceride lipase (MGL), also known as monoacylglycerol lipase (MAGL), has emerged as a promising approach for treating neurological diseases. To gain useful insights in the design of agents with balanced potency and reactivity, we investigated the mechanism of MGL...

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Detalles Bibliográficos
Autores principales: Galvani, Francesca, Scalvini, Laura, Rivara, Silvia, Lodola, Alessio, Mor, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198976/
https://www.ncbi.nlm.nih.gov/pubmed/35580195
http://dx.doi.org/10.1021/acs.jcim.2c00140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198976/
https://www.ncbi.nlm.nih.gov/pubmed/35580195
http://dx.doi.org/10.1021/acs.jcim.2c00140

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