α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

α-synuclein (α-Syn) is intimately linked to synucleinopathies like Parkinson’s disease and dementia with Lewy bodies. However, the pathophysiological mechanisms that are triggered by this protein are still largely enigmatic. α-Syn overabundance may cause neurodegeneration through protein accumulatio...

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Detalles Bibliográficos
Autores principales: Leite, Kristian, Garg, Pretty, Spitzner, F. Paul, Guerin Darvas, Sofia, Bähr, Mathias, Priesemann, Viola, Kügler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199018/
https://www.ncbi.nlm.nih.gov/pubmed/35721317
http://dx.doi.org/10.3389/fnmol.2022.868790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199018/
https://www.ncbi.nlm.nih.gov/pubmed/35721317
http://dx.doi.org/10.3389/fnmol.2022.868790

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