Cargando…
Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice
Parkinson’s disease, the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. FBXO7 (F-box protein only 7) (PARK15) mutations cause early-onset Parkinson’s disease. FBXO7 is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin liga...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199167/ https://www.ncbi.nlm.nih.gov/pubmed/35701754 http://dx.doi.org/10.1186/s13041-022-00936-5 |