Productivity and quality improvement for a symmetric bispecific antibody through the application of intensified perfusion cell culture

BACKGROUND: Aggregation, fragmentation, and low yield are issues frequently found during the cell culture process of bispecific antibodies (bsAbs), whose inherent complexity likely plays a role in causing these issues. METHODS: In this study, we made a head-to-head comparison between fed-batch cell...

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Detalles Bibliográficos
Autores principales: Qin, Yongjun, Ma, Rongmei, Li, Yang, Li, Yifeng, Chen, Gong, Zhou, Weichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199187/
https://www.ncbi.nlm.nih.gov/pubmed/35719210
http://dx.doi.org/10.1093/abt/tbac009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199187/
https://www.ncbi.nlm.nih.gov/pubmed/35719210
http://dx.doi.org/10.1093/abt/tbac009

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