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Productivity and quality improvement for a symmetric bispecific antibody through the application of intensified perfusion cell culture
BACKGROUND: Aggregation, fragmentation, and low yield are issues frequently found during the cell culture process of bispecific antibodies (bsAbs), whose inherent complexity likely plays a role in causing these issues. METHODS: In this study, we made a head-to-head comparison between fed-batch cell...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199187/ https://www.ncbi.nlm.nih.gov/pubmed/35719210 http://dx.doi.org/10.1093/abt/tbac009 |