Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke

BACKGROUND: Neonatal stroke is a devastating insult that can lead to life-long impairments. In response to hypoxic–ischaemic injury, there is loss of neurons and glia as well as a neuroinflammatory response mediated by resident immune cells, including microglia and astrocytes, which can exacerbate d...

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Detalles Bibliográficos
Autores principales: Bourget, Clara, Adams, Kelsey V., Morshead, Cindi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199194/
https://www.ncbi.nlm.nih.gov/pubmed/35705953
http://dx.doi.org/10.1186/s12974-022-02487-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199194/
https://www.ncbi.nlm.nih.gov/pubmed/35705953
http://dx.doi.org/10.1186/s12974-022-02487-x

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