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Perspective on the Relationship between GABA(A) Receptor Activity and the Apparent Potency of an Inhibitor

Background: In electrophysiological experiments, inhibition of a receptor-channel, such as the GABA(A) receptor, is measured by co-applying an agonist producing a predefined control response with an inhibitor to calculate the fraction of the control response remaining in the presence of the inhibito...

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Detalles Bibliográficos
Autores principales: Germann, Allison L., Pierce, Spencer R., Evers, Alex S., Steinbach, Joe Henry, Akk, Gustav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199547/
https://www.ncbi.nlm.nih.gov/pubmed/34784870
http://dx.doi.org/10.2174/1570159X19666211104142433