Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting

High yield production of recombinant HIV SOSIP envelope (Env) trimers has proven elusive as numerous disulfide bonds, proteolytic cleavage and extensive glycosylation pose high demands on the host cell machinery and stress imposed by accumulation of misfolded proteins may ultimately lead to cellular...

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Detalles Bibliográficos
Autores principales: Rosenberg, Yvonne J., Jiang, Xiaoming, Lees, Jonathan P., Urban, Lori A., Mao, Lingjun, Sack, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200074/
https://www.ncbi.nlm.nih.gov/pubmed/35705669
http://dx.doi.org/10.1038/s41598-022-14075-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200074/
https://www.ncbi.nlm.nih.gov/pubmed/35705669
http://dx.doi.org/10.1038/s41598-022-14075-3

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