Practical asymmetric amine nucleophilic approach for the modular construction of protected α-quaternary amino acids

We report the first amine nucleophilic approach for the modular construction of enantioenriched protected α-quaternary amino acids. The key to success is the use of an alcohol solvent, which makes a rationally designed COOMe-bonded Cu-allenylidene electrophilic intermediate stable enough to couple w...

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Detalles Bibliográficos
Autores principales: Liu, Teng, Ni, Shaofei, Guo, Wusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200120/
https://www.ncbi.nlm.nih.gov/pubmed/35774153
http://dx.doi.org/10.1039/d2sc02318k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200120/
https://www.ncbi.nlm.nih.gov/pubmed/35774153
http://dx.doi.org/10.1039/d2sc02318k

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