CD38 reduces mitochondrial fitness and cytotoxic T cell response against viral infection in lupus patients by suppressing mitophagy

Infection is one of the major causes of mortality in patients with systemic lupus erythematosus (SLE). We previously found that CD38, an ectoenzyme that regulates the production of NAD(+), is up-regulated in CD8(+) T cells of SLE patients and correlates with the risk of infection. Here, we report th...

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Detalles Bibliográficos
Autores principales: Chen, Ping-Min, Katsuyama, Eri, Satyam, Abhigyan, Li, Hao, Rubio, Jose, Jung, Sungwook, Andrzejewski, Sylvia, Becherer, J. David, Tsokos, Maria G., Abdi, Reza, Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200274/
https://www.ncbi.nlm.nih.gov/pubmed/35704572
http://dx.doi.org/10.1126/sciadv.abo4271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200274/
https://www.ncbi.nlm.nih.gov/pubmed/35704572
http://dx.doi.org/10.1126/sciadv.abo4271

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