Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T(reg) differentiation via up-regulating Nr4a2

Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (T(regs)) critical for establishing immune tolerance, we show here that SRC2 stimulates T(reg) differentiation. SRC2 is dispensable for t...

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Detalles Bibliográficos
Autores principales: Zhang, Wencan, Cao, Xu, Zhong, Xiancai, Wu, Hongmin, Feng, Mingye, Gwack, Yousang, Noah, Isakov, Sun, Zuoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200286/
https://www.ncbi.nlm.nih.gov/pubmed/35704583
http://dx.doi.org/10.1126/sciadv.abn7662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200286/
https://www.ncbi.nlm.nih.gov/pubmed/35704583
http://dx.doi.org/10.1126/sciadv.abn7662

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