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Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T(reg) differentiation via up-regulating Nr4a2
Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (T(regs)) critical for establishing immune tolerance, we show here that SRC2 stimulates T(reg) differentiation. SRC2 is dispensable for t...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200286/ https://www.ncbi.nlm.nih.gov/pubmed/35704583 http://dx.doi.org/10.1126/sciadv.abn7662 |