Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins

Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly induced a concentration-dependent delay in mitotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Yunes, Sarah A., Willoughby, Jennifer L. S., Kwan, Julian H., Biagi, Jessica M., Pokharel, Niranjana, Chin, Hang Gyeong, York, Emily A., Su, Kuan-Chung, George, Kelly, Shah, Jagesh V., Emili, Andrew, Schaus, Scott E., Hansen, Ulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200292/
https://www.ncbi.nlm.nih.gov/pubmed/35704642
http://dx.doi.org/10.1371/journal.pone.0268857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200292/
https://www.ncbi.nlm.nih.gov/pubmed/35704642
http://dx.doi.org/10.1371/journal.pone.0268857

Ejemplares similares