Clustered 8-Oxo-Guanine Mutations and Oncogenic Gene Fusions in Microsatellite-Unstable Colorectal Cancer

Colorectal carcinomas (CRCs) with microsatellite-instability (MSI) are enriched for oncogenic kinase fusions (KFs), including NTRK1, RET, and BRAF, but the mechanism underlying this finding is unclear. METHODS: The genomic profiles of 32,218 advanced CRC tumor specimens were analyzed to assess the f...

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Detalles Bibliográficos
Autores principales: Madison, Russell W., Hu, Xiaoju, Ramanan, Vivek, Xu, Zhuxuan, Huang, Richard S.P., Sokol, Ethan S., Frampton, Garrett M., Schrock, Alexa B., Ali, Siraj M., Ganesan, Shridar, De, Subhajyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200390/
https://www.ncbi.nlm.nih.gov/pubmed/35584350
http://dx.doi.org/10.1200/PO.21.00477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200390/
https://www.ncbi.nlm.nih.gov/pubmed/35584350
http://dx.doi.org/10.1200/PO.21.00477

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