GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia. Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and rearrangement of the lipid content of cardiomyocyte and promote oxidative stress. As a newly defined lipid peroxidation-related cell...

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Detalles Bibliográficos
Autores principales: Xu, Kai, Liu, Xiang, Wen, Bin, Liu, Yazhou, Zhang, Wei, Hu, Xiaolin, Chen, Ling, Hang, Weijian, Chen, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200982/
https://www.ncbi.nlm.nih.gov/pubmed/35722096
http://dx.doi.org/10.3389/fcvm.2022.907747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200982/
https://www.ncbi.nlm.nih.gov/pubmed/35722096
http://dx.doi.org/10.3389/fcvm.2022.907747

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