Cargando…

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia. Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and rearrangement of the lipid content of cardiomyocyte and promote oxidative stress. As a newly defined lipid peroxidation-related cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Kai, Liu, Xiang, Wen, Bin, Liu, Yazhou, Zhang, Wei, Hu, Xiaolin, Chen, Ling, Hang, Weijian, Chen, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200982/ https://www.ncbi.nlm.nih.gov/pubmed/35722096 http://dx.doi.org/10.3389/fcvm.2022.907747

Ejemplares similares

Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia
por: Ntziachristos, Panagiotis, et al.
Publicado: (2014)

Histone lysine demethylases in Drosophila melanogaster
por: Holowatyj, Andreana, et al.
Publicado: (2015)

Histone demethylase lysine demethylase 5B in development and cancer
por: Han, Mengjiao, et al.
Publicado: (2016)

Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
por: Abu-Hanna, Jeries, et al.
Publicado: (2022)

Histone lysine demethylases in mammalian embryonic development
por: Shen, Hongjie, et al.
Publicado: (2017)

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment
por: Burgold, Thomas, et al.
Publicado: (2008)

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
por: Manna, Sugata, et al.
Publicado: (2015)

The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
por: Sui, Aixia, et al.
Publicado: (2017)

Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
por: Rosales, Wendy, et al.
Publicado: (2016)

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean
por: Liu, Mengshi, et al.
Publicado: (2022)

The emerging role of histone lysine demethylases in prostate cancer
por: Crea, Francesco, et al.
Publicado: (2012)

Androgen Receptor and Histone Lysine Demethylases in Ovine Placenta
por: Cleys, Ellane R., et al.
Publicado: (2015)

Targeting histone lysine demethylases — Progress, challenges, and the future()
por: Thinnes, Cyrille C., et al.
Publicado: (2014)

Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma
por: Zheng, Yang, et al.
Publicado: (2020)

The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation
por: Tang, Xin, et al.
Publicado: (2019)

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model
por: Wang, Jing-Jing, et al.
Publicado: (2022)

Prominent role of histone lysine demethylases in cancer epigenetics and therapy
por: Janardhan, Avilala, et al.
Publicado: (2018)

Canagliflozin Attenuates Lipotoxicity in Cardiomyocytes by Inhibiting Inflammation and Ferroptosis through Activating AMPK Pathway
por: Zhang, Wanqiu, et al.
Publicado: (2023)

KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development
por: Shpargel, Karl B., et al.
Publicado: (2014)

Expression pattern of histone lysine-specific demethylase 6B in gastric cancer
por: Wang, Shujun, et al.
Publicado: (2021)

Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro
por: Lohse, Brian, et al.
Publicado: (2013)

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
por: Majello, Barbara, et al.
Publicado: (2019)

Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
por: Chianese, Ugo, et al.
Publicado: (2022)

Epigenetic Control of Muscle Stem Cells: Focus on Histone Lysine Demethylases
por: Cicciarello, Delia, et al.
Publicado: (2022)

Distinct Roles of Histone Lysine Demethylases and Methyltransferases in Developmental Eye Disease
por: Reis, Linda M., et al.
Publicado: (2023)

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
por: Li, Yunan, et al.
Publicado: (2018)

Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation
por: Ding, Mina, et al.
Publicado: (2023)

The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation
por: Hung, Peir-Haur, et al.
Publicado: (2022)

Machine-Learning-Enabled Virtual Screening for Inhibitors of Lysine-Specific Histone Demethylase 1
por: Zhou, Jiajun, et al.
Publicado: (2021)

The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer
por: Li, Jiaping, et al.
Publicado: (2019)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
por: Walport, Louise J., et al.
Publicado: (2016)

Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
por: Beilner, Daniel, et al.
Publicado: (2020)

Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma
por: Kim, Sangchul, et al.
Publicado: (2019)

The role of histone lysine demethylases in cancer cells’ resistance to tyrosine kinase inhibitors
por: White, Jasmine Cassar, et al.
Publicado: (2019)

Modulation of the activity of histone lysine methyltransferases and demethylases by curcumin analog in leukaemia cells
por: Sawesi, Suhila, et al.
Publicado: (2022)

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery
por: Das, Nando Dulal, et al.
Publicado: (2023)

17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma
por: Singh, Shivendra, et al.
Publicado: (2020)

Chemical Biology of Lysine Demethylases
por: Heightman, Tom D
Publicado: (2011)

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays
por: Lobo-Silva, Jessica, et al.
Publicado: (2020)

Fibrosis—the tale of H3K27 histone methyltransferases and demethylases
por: Basta, Morgan D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_302bemrgr04vrerr4ggosuvg7f