mD-UPLC-MS/MS: Next Generation of mAb Characterization by Multidimensional Ultraperformance Liquid Chromatography-Mass Spectrometry and Parallel On-Column LysC and Trypsin Digestion

[Image: see text] For the past few years, multidimensional liquid chromatography-mass spectrometry (LC-MS) systems have been commonly used to characterize post-translational modifications (PTMs) of therapeutic antibodies (mAbs). In most cases, this is performed by fractionation of charge variants by...

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Detalles Bibliográficos
Autores principales: Oezipek, Saban, Hoelterhoff, Sina, Breuer, Simon, Bell, Christian, Bathke, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201819/
https://www.ncbi.nlm.nih.gov/pubmed/35545869
http://dx.doi.org/10.1021/acs.analchem.1c04450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201819/
https://www.ncbi.nlm.nih.gov/pubmed/35545869
http://dx.doi.org/10.1021/acs.analchem.1c04450

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