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Next Generation Risk Assessment of the Anti-Androgen Flutamide Including the Contribution of Its Active Metabolite Hydroxyflutamide

In next generation risk assessment (NGRA), non-animal approaches are used to quantify the chemical concentrations required to trigger bioactivity responses, in order to assure safe levels of human exposure. A limitation of many in vitro bioactivity assays, which are used in an NGRA context as new ap...

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Detalles Bibliográficos
Autores principales: van Tongeren, Tessa C.A., Carmichael, Paul L., Rietjens, Ivonne M.C.M., Li, Hequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201820/
https://www.ncbi.nlm.nih.gov/pubmed/35722059
http://dx.doi.org/10.3389/ftox.2022.881235