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Increased Frequency of Indels in Hypervariable Regions of SARS-CoV-2 Proteins—A Possible Signature of Adaptive Selection

Most attention in the surveillance of evolving SARS-CoV-2 genome has been centered on nucleotide substitutions in the spike glycoprotein. We show that, as the pandemic extends into its second year, the numbers and ratio of genomes with in-frame insertions and deletions (indels) increases significant...

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Detalles Bibliográficos
Autores principales: Alisoltani, Arghavan, Jaroszewski, Lukasz, Iyer, Mallika, Iranzadeh, Arash, Godzik, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201826/
https://www.ncbi.nlm.nih.gov/pubmed/35719386
http://dx.doi.org/10.3389/fgene.2022.875406