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Optimization of Automated Synthesis of Amide-Linked RNA
[Image: see text] The recent FDA approval of several antisense and siRNA drugs illustrates the utility of nucleic acid chemical modifications, but numerous challenges remain for generalized nucleic acid therapeutics, urging the exploration of new modification strategies. Replacing backbone phosphate...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201902/ https://www.ncbi.nlm.nih.gov/pubmed/35721988 http://dx.doi.org/10.1021/acsomega.2c02742 |