Cargando…

4-Chlorophenyl-N-furfuryl-1,2,4-triazole Methylacetamides as Significant 15-Lipoxygenase Inhibitors: an Efficient Approach for Finding Lead Anti-inflammatory Compounds

[Image: see text] Lipoxygenases (LOXs) are a class of enzymes that catalyze the production of pro-inflammatory mediators, such as leukotrienes and lipoxins, via an arachidonic acid cascade as soon as they are released from the membrane phospholipids after tissue injury. In continuation of our effort...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yasin, Muhammad, Shahid, Wardah, Ashraf, Muhammad, Saleem, Muhammad, Muzaffar, Saima, Aziz-ur-Rehman, Ejaz, Syed Abid, Saeed, Amna, Majer, Thomas, Bhattarai, Keshab, Riaz, Naheed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202051/ https://www.ncbi.nlm.nih.gov/pubmed/35721976 http://dx.doi.org/10.1021/acsomega.2c01439

Ejemplares similares

Discovery of Phenylcarbamoylazinane-1,2,4-Triazole Amides Derivatives as the Potential Inhibitors of Aldo-Keto Reductases (AKR1B1 & AKRB10): Potential Lead Molecules for Treatment of Colon Cancer
por: Saeed, Amna, et al.
Publicado: (2022)

1-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one
por: Kattimani, Pramod P., et al.
Publicado: (2014)

4-Amino-3-(4-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Natarajan, Sampath, et al.
Publicado: (2012)

4-(4-Chlorophenyl)-5-(4-nitrophenyl)-3-phenyl-4H-1,2,4-triazole
por: Hu, Jing, et al.
Publicado: (2007)

Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein
por: Olğaç, Abdurrahman, et al.
Publicado: (2023)

2-[4-Benzyl-5-(2-furyl)-4H-1,2,4-triazol-3-ylsulfanyl]acetamide
por: Zareef, Muhammad, et al.
Publicado: (2008)

3-{[5-(4-Chlorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-4-m-tolyl-1H-1,2,4-triazole-5(4H)-thione
por: Farrukh, Muhammad A., et al.
Publicado: (2013)

5-Amino-3-(4H-1,2,4-triazol-4-yl)-1H-1,2,4-triazole
por: Liu, Bing, et al.
Publicado: (2012)

3-(2-Chlorophenyl)-4-(4-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Nikoo, Abbas, et al.
Publicado: (2011)

Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues
por: Abdullah Asif, Hafiz Muhammad, et al.
Publicado: (2022)

Hydrophobic Collapse in N-Methylacetamide–Water Mixtures
por: Salamatova, Evgeniia, et al.
Publicado: (2018)

Crystal structure of 3-(adamantan-1-yl)-4-(4-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Al-Wabli, Reem I., et al.
Publicado: (2015)

4-Ethyl-3-(3-pyridyl)-1H-1,2,4-triazole-5(4H)-thione 0.095-hydrate
por: Zareef, Muhammad, et al.
Publicado: (2008)

4-Benzyl-3-(2-furyl)-1H-1,2,4-triazole-5(4H)-thione hemihydrate
por: Zareef, Muhammad, et al.
Publicado: (2008)

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles.
por: Jørgensen, Kåre B., et al.
Publicado: (2001)

4-(1,2,4-Triazol-1-yl)aniline
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

[Hydrogen bis(1,2,4-triazole)] 1,2,4-triazolium bis(3-carboxy-4-hydroxybenzenesulfonate) 1,2,4-triazole disolvate
por: Qiu, Ming-qiang
Publicado: (2010)

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles
por: Gautun, Odd R., et al.
Publicado: (2001)

An insight on medicinal attributes of 1,2,4-triazoles
por: Aggarwal, Ranjana, et al.
Publicado: (2020)

1,2,4-Triazoles as Important Antibacterial Agents
por: Strzelecka, Małgorzata, et al.
Publicado: (2021)

The antinociceptive effect of 4-substituted derivatives of 5-(4-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in mice
por: Joanna, Listos, et al.
Publicado: (2013)

5-(3-Methoxyphenethyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ol
por: Hanif, Muhammad, et al.
Publicado: (2008)

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
por: Sultan, Aeysha, et al.
Publicado: (2020)

2-(4H-1,2,4-Triazol-4-yl)pyrimidine
por: Wang, Qian, et al.
Publicado: (2011)

2-(4H-1,2,4-Triazol-4-yl)phenol
por: Zhao, Wang, et al.
Publicado: (2010)

5-(2-Methoxybenzyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ol
por: Hanif, Muhammad, et al.
Publicado: (2009)

4-n-Butyl-3-(3-methylphenyl)-1H-1,2,4-triazol-5(4H)-one
por: Akhtar, Tashfeen, et al.
Publicado: (2008)

Di-μ-aqua-bis[diaquabis(thiocyanato-κN)iron(II)] 4-(4-chlorophenyl)-1,2,4-triazole hexasolvate
por: Li, Xiuhua, et al.
Publicado: (2008)

1-{4-[(1H-1,2,4-Triazol-1-yl)methyl]benzyl}-1H-1,2,4-triazol-4-ium perchlorate
por: Hu, Zhao-Jian, et al.
Publicado: (2010)

3-(3-Methoxybenzyl)-4-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Hanif, Muhammad, et al.
Publicado: (2008)

1H-1,2,4-Triazole-3-carboxamide
por: Xie, Qing-Ruo
Publicado: (2008)

3-Nitro-1H-1,2,4-triazole
por: Hemamalini, Madhukar, et al.
Publicado: (2010)

Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes
por: Boraei, Ahmed T. A., et al.
Publicado: (2016)

(Z)-1,3-Bis(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
por: Dai, Ling-Ling, et al.
Publicado: (2012)

4-Amino-3,5-dimethyl-4H-1,2,4-triazole
por: Li, Daojin, et al.
Publicado: (2008)

Thermodynamic Analysis and Pyrolysis Mechanism of 4,4′-Azobis-1,2,4-triazole
por: Qin, Kaiyi, et al.
Publicado: (2023)

Bis(4H-1,2,4-triazol-3-yl)disulfane
por: Liu, Dongsheng, et al.
Publicado: (2007)

Design, Synthesis, and Targeted Delivery of Fluorescent 1,2,4-Triazole–Peptide Conjugates to Pediatric Brain Tumor Cells
por: Ajmal, Muhammad, et al.
Publicado: (2019)

4-[4-(Diethylamino)benzylideneamino]-4H-1,2,4-triazole
por: Pan, Jian Xin, et al.
Publicado: (2008)

N-(2-Chlorophenyl)-2-({5-[4-(methylsulfanyl)benzyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_na24jha05200o8jngu0ov8ru0r