Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike gene

The high mutation rate of SARS-CoV-2 largely complicates our control of the pandemic. In particular, it is currently unclear why the spike (S) gene has an extraordinarily high mutation rate among all SARS-CoV-2 genes. By analyzing the occurrence of fixed synonymous mutations between SARS-CoV-2 and R...

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Detalles Bibliográficos
Autores principales: Liu, Xueyan, Liu, Xuan, Zhou, Jie, Dong, Yu, Jiang, Wen, Jiang, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202584/
https://www.ncbi.nlm.nih.gov/pubmed/35508354
http://dx.doi.org/10.1261/rna.079160.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202584/
https://www.ncbi.nlm.nih.gov/pubmed/35508354
http://dx.doi.org/10.1261/rna.079160.122

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