Cargando…

Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike gene

The high mutation rate of SARS-CoV-2 largely complicates our control of the pandemic. In particular, it is currently unclear why the spike (S) gene has an extraordinarily high mutation rate among all SARS-CoV-2 genes. By analyzing the occurrence of fixed synonymous mutations between SARS-CoV-2 and R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xueyan, Liu, Xuan, Zhou, Jie, Dong, Yu, Jiang, Wen, Jiang, Wenqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202584/ https://www.ncbi.nlm.nih.gov/pubmed/35508354 http://dx.doi.org/10.1261/rna.079160.122

Ejemplares similares

C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolution
por: Li, Yan, et al.
Publicado: (2022)

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection
por: Letarov, Andrey V., et al.
Publicado: (2020)

Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome
por: Jiang, Cizhong, et al.
Publicado: (2006)

How Our Neanderthal Genes Affect the COVID-19 Mortality: Iran and Mongolia, Two Countries with the Same SARS-CoV-2 Mutation Cluster but Different Mortality Rates
por: Mortazavi, S. A. R., et al.
Publicado: (2021)

Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease
por: Krishnamoorthy, Navaneethakrishnan, et al.
Publicado: (2021)

Computer aided prediction and identification of potential epitopes in the receptor binding domain (RBD) of spike (S) glycoprotein of MERS-CoV
por: ali, Mohammad Tuhin, et al.
Publicado: (2014)

Quackery Rampant
Publicado: (1860)

Quackery Rampant
Publicado: (1858)

Quackery Rampant
por: Moss, R. E.
Publicado: (1890)

Quackery Rampant
Publicado: (1896)

Irruption Theory: A Novel Conceptualization of the Enactive Account of Motivated Activity
por: Froese, Tom
Publicado: (2023)

SARS-CoV-2 and viral sepsis: observations and hypotheses
por: Li, Hui, et al.
Publicado: (2020)

The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
por: Bian, Zhongzheng, et al.
Publicado: (2023)

The decreased SIRT1 level may account for the lipid profile in chronic kidney disease
por: Chen, Gang, et al.
Publicado: (2019)

The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike protein
por: Tan, Yee-Joo
Publicado: (2005)

El barón rampante
por: Calvino, Italo
Publicado: (1985)

El baron rampante /
por: Calvino, Italo
Publicado: (1980)

Adolescent rampant caries
por: Namita,, et al.
Publicado: (2012)

Il barone rampante
por: Calvino, Italo
Publicado: (1967)

Rampant Cheating by Pathogens?
por: Rundell, Ethan A., et al.
Publicado: (2016)

Hypothesis: Single Actomyosin Properties Account for Ensemble Behavior in Active Muscle Shortening and Isometric Contraction
por: Månsson, Alf
Publicado: (2020)

SARS‐CoV‐2 infection and cancer: Evidence for and against a role of SARS‐CoV‐2 in cancer onset
por: Stingi, Aureliano, et al.
Publicado: (2021)

El barón rampante : novela
por: Calvino, Italo
Publicado: (1970)

Autophagy: The Potential Link between SARS-CoV-2 and Cancer
por: Habibzadeh, Parham, et al.
Publicado: (2021)

The Pernicious Tendencies of Rampant Organization
Publicado: (1907)

The Pernicious Tendencies of Rampant Organization
Publicado: (1907)

Potential interaction between lysophosphatidic acid and tumor-associated macrophages in ovarian carcinoma
por: Feng, Ying, et al.
Publicado: (2020)

Does SARS-CoV-2 Induce IgG4 Synthesis to Evade the Immune System?
por: Rubio-Casillas, Alberto, et al.
Publicado: (2023)

Sphingosine-1-Phosphate as Lung and Cardiac Vasculature Protecting Agent in SARS-CoV-2 Infection
por: Karam, Manale, et al.
Publicado: (2023)

JAK Inhibitors as Potential Therapeutic Strategy for the Dilemma of Psoriasis Concurrent with Dermatomyositis in the SARS-CoV-2 Era
por: Xu, Qiannan, et al.
Publicado: (2023)

The role of JMJD6/U2AF65/AR-V7 axis in castration-resistant prostate cancer progression
por: Tong, Dali
Publicado: (2021)

SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
por: Meacci, Elisabetta, et al.
Publicado: (2020)

Proposed Algorithm for Integrated Management of TB-SARS-CoV-2 Co-Infection in a TB-Endemic Country
por: Mertaniasih, Ni Made, et al.
Publicado: (2022)

Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories
por: Simmonds, P.
Publicado: (2020)

The role of mutation in the new cancer paradigm
por: Prehn, Richmond T
Publicado: (2005)

In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection
por: Martorana, Annamaria, et al.
Publicado: (2020)

SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy—Is there a link?
por: Balmant, Bianca D., et al.
Publicado: (2021)

Induction of Gut Microbial Tryptamine by SARS-CoV-2 in Nonhuman Primate Model Consistent with Tryptamine-Induced Model of Neurodegeneration
por: Paley, Elena L.
Publicado: (2021)

The Clinical Laboratory: I. Rampant Pathology
Publicado: (1912)

Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity
por: Mendonca, Patricia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j3dnmb68tbn1umhvtgqra2vcri