Cm28, a scorpion toxin having a unique primary structure, inhibits K(V)1.2 and K(V)1.3 with high affinity

The Cm28 in the venom of Centruroides margaritatus is a short peptide consisting of 27 amino acid residues with a mol wt of 2,820 D. Cm28 has <40% similarity with other known α-KTx from scorpions and lacks the typical functional dyad (lysine–tyrosine) required to block K(V) channels. However, its...

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Detalles Bibliográficos
Autores principales: Naseem, Muhammad Umair, Carcamo-Noriega, Edson, Beltrán-Vidal, José, Borrego, Jesus, Szanto, Tibor G., Zamudio, Fernando Z., Delgado-Prudencio, Gustavo, Possani, Lourival D., Panyi, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202693/
https://www.ncbi.nlm.nih.gov/pubmed/35699659
http://dx.doi.org/10.1085/jgp.202213146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202693/
https://www.ncbi.nlm.nih.gov/pubmed/35699659
http://dx.doi.org/10.1085/jgp.202213146

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