Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia

CONTEXT: The causative link between circulating glucocorticoid excess and osteoporosis is well-established. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which increases local cortisol production, is expressed in human osteoblasts and its activity increases with age. OBJECTIVE: We h...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbas, Afroze, Schini, Marian, Ainsworth, Gemma, Brown, Sarah R, Oughton, Jamie, Crowley, Rachel K, Cooper, Mark S, Fairclough, Rebecca J, Eastell, Richard, Stewart, Paul M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202729/
https://www.ncbi.nlm.nih.gov/pubmed/35275196
http://dx.doi.org/10.1210/clinem/dgac100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202729/
https://www.ncbi.nlm.nih.gov/pubmed/35275196
http://dx.doi.org/10.1210/clinem/dgac100

Ejemplares similares