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Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia

CONTEXT: The causative link between circulating glucocorticoid excess and osteoporosis is well-established. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which increases local cortisol production, is expressed in human osteoblasts and its activity increases with age. OBJECTIVE: We h...

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Detalles Bibliográficos
Autores principales:	Abbas, Afroze, Schini, Marian, Ainsworth, Gemma, Brown, Sarah R, Oughton, Jamie, Crowley, Rachel K, Cooper, Mark S, Fairclough, Rebecca J, Eastell, Richard, Stewart, Paul M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202729/ https://www.ncbi.nlm.nih.gov/pubmed/35275196 http://dx.doi.org/10.1210/clinem/dgac100

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