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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by uncontrolled complement activation; effective and approved treatments include terminal complement inhibition. This study assessed whether combination cemdisiran (an investigational N-acetylgalactosamine-conjugated RNAi therapeutic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202903/ https://www.ncbi.nlm.nih.gov/pubmed/35709087 http://dx.doi.org/10.1371/journal.pone.0269749 |