Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex

DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified that exhibit selectivity for G4s over alternative forms of DNA, such as the ubiquitous duplex. We posit that the lack of current ligand spec...

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Detalles Bibliográficos
Autores principales: Monsen, Robert C., Maguire, Jon M., DeLeeuw, Lynn W., Chaires, Jonathan B., Trent, John O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202945/
https://www.ncbi.nlm.nih.gov/pubmed/35709230
http://dx.doi.org/10.1371/journal.pone.0270165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202945/
https://www.ncbi.nlm.nih.gov/pubmed/35709230
http://dx.doi.org/10.1371/journal.pone.0270165

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