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T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin

The reservoir of latently HIV-1 infected cells is heterogeneous. To achieve an HIV-1 cure, the reservoir of activatable proviruses must be eliminated while permanently silenced proviruses may be tolerated. We have developed a method to assess the proviral nuclear microenvironment in single cells. In...

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Detalles Bibliográficos
Autores principales: Lindqvist, Birgitta, Jütte, Bianca B., Love, Luca, Assi, Wlaa, Roux, Julie, Sönnerborg, Anders, Tezil, Tugsan, Verdin, Eric, Svensson, J. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203004/
https://www.ncbi.nlm.nih.gov/pubmed/35666761
http://dx.doi.org/10.1371/journal.ppat.1010555