Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9

The development of high efficiency, central nervous system (CNS) targeting AAV-based gene therapies is necessary to address challenges in both pre-clinical and clinical investigations. The engineered capsids, AAV.PHP.B and AAV.PHP.eB, show vastly improved blood-brain barrier penetration compared to...

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Detalles Bibliográficos
Autores principales: Chatterjee, Diptaman, Marmion, David J., McBride, Jodi L., Manfredsson, Fredric P., Butler, David, Messer, Anne, Kordower, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203269/
https://www.ncbi.nlm.nih.gov/pubmed/33753910
http://dx.doi.org/10.1038/s41434-021-00244-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203269/
https://www.ncbi.nlm.nih.gov/pubmed/33753910
http://dx.doi.org/10.1038/s41434-021-00244-y

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