Cargando…

Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9

The development of high efficiency, central nervous system (CNS) targeting AAV-based gene therapies is necessary to address challenges in both pre-clinical and clinical investigations. The engineered capsids, AAV.PHP.B and AAV.PHP.eB, show vastly improved blood-brain barrier penetration compared to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chatterjee, Diptaman, Marmion, David J., McBride, Jodi L., Manfredsson, Fredric P., Butler, David, Messer, Anne, Kordower, Jeffrey H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203269/ https://www.ncbi.nlm.nih.gov/pubmed/33753910 http://dx.doi.org/10.1038/s41434-021-00244-y

Ejemplares similares

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice
por: Blanc, Fabian, et al.
Publicado: (2022)

CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
por: Mathiesen, Sophie N., et al.
Publicado: (2020)

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
por: Kanaan, Nicholas M., et al.
Publicado: (2017)

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors
por: Xu, Guangxue, et al.
Publicado: (2022)

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna
por: Hinderer, Christian, et al.
Publicado: (2014)

AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice
por: Lukashchuk, Vera, et al.
Publicado: (2016)

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
por: Arotcarena, Marie-Laure, et al.
Publicado: (2021)

Puncture of the Cisterna Magna
por: Stewart, Donald
Publicado: (1929)

Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B
por: Jackson, Kasey L., et al.
Publicado: (2016)

Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery
por: Smith, Edward J, et al.
Publicado: (2021)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B
por: Jackson, Kasey L., et al.
Publicado: (2016)

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors
por: van Beelen, Edward S. A., et al.
Publicado: (2022)

Manic Episode Associated with Mega Cisterna Magna
por: Turan, Tayfun, et al.
Publicado: (2010)

Mature teratoma of the cisterna magna in an adult patient
por: Jafri, Syeda Kubra Kishwar, et al.
Publicado: (2022)

GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter
por: Hoshino, Chiaki, et al.
Publicado: (2021)

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption
por: Orlowski, Alejandro, et al.
Publicado: (2020)

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector
por: Murlidharan, Giridhar, et al.
Publicado: (2016)

Selectively Imaging Cranial Sensory Ganglion Neurons Using AAV-PHP.S
por: Asencor, Andoni I., et al.
Publicado: (2022)

Cisterna magna reconstruction with arachnoid suturing in brainstem surgery
por: Keleş, Abdullah, et al.
Publicado: (2019)

Schizophrenia and Mega cisterna magna: a Case report
por: Güneysu, E. E., et al.
Publicado: (2023)

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats
por: Jackson, Kasey L, et al.
Publicado: (2015)

A comparison of AAV-vector production methods for gene therapy and preclinical assessment
por: Davidsson, Marcus, et al.
Publicado: (2020)

Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle
por: Okamoto, Kazuki, et al.
Publicado: (2023)

Structural basis of receptor usage by the engineered capsid AAV-PHP.eB
por: Jang, Seongmin, et al.
Publicado: (2022)

Preferred transduction with AAV8 and AAV9 via thalamic administration in the MPS IIIB model: A comparison of four rAAV serotypes
por: Gilkes, J.A., et al.
Publicado: (2015)

A road less travelled: the centenary of cisterna magna puncture
por: Lutters, Bart, et al.
Publicado: (2020)

Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations
por: Surdyka, Magdalena, et al.
Publicado: (2022)

Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9
por: Okada, Hironori, et al.
Publicado: (2013)

Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications
por: Wang, Mei, et al.
Publicado: (2016)

Intrathecal Pump Implantation in the Cisterna Magna for Treating Intractable Cancer Pain
por: Lou, Yaling, et al.
Publicado: (2018)

Mega cisterna magna in bipolar mood disorder: a case report
por: Yazici, Esra, et al.
Publicado: (2021)

Bilateral Coronal Synostosis and Mega Cisterna Magna: A Case Report
por: Ballard, Craig, et al.
Publicado: (2022)

Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy
por: Kashiwakura, Yuji, et al.
Publicado: (2023)

Intravenous Injection of an AAV-PHP.B Vector Encoding Human Acid α-Glucosidase Rescues Both Muscle and CNS Defects in Murine Pompe Disease
por: Lim, Jeong-A, et al.
Publicado: (2019)

AAV-mediated photoreceptor transduction of the pig cone-enriched retina
por: Mussolino, C, et al.
Publicado: (2011)

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors
por: Moulay, Gilles, et al.
Publicado: (2010)

Role of Essential Metal Ions in AAV Vector-Mediated Transduction
por: Rambhai, Himanshu K., et al.
Publicado: (2020)

Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
por: Madrakhimov, Sanjar Batirovich, et al.
Publicado: (2020)

Global CNS Gene Delivery and Evasion of Anti-AAV Neutralizing Antibodies by Intrathecal AAV Administration in Non-Human Primates
por: Gray, Steven J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ujvs502pch3utqnb2daiqtggvp