First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model

The only treatment tested for growth hormone receptor (GHR) defective Laron Syndrome (LS) is injections of recombinant insulin-like-growth factor 1 (rhIGF1). The response is suboptimal and associated with progressive obesity. In this study, we treated 4–5-week-old Laron dwarf mice (GHR−/−) with an a...

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Detalles Bibliográficos
Autores principales: Sia, Kian Chuan, Gan, Shu Uin, Mohd Rodhi, Siti Humairah, Fu, Zhen Ying, Kopchick, John J., Waters, Michael J., Lee, Kok Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203273/
https://www.ncbi.nlm.nih.gov/pubmed/35105948
http://dx.doi.org/10.1038/s41434-022-00313-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203273/
https://www.ncbi.nlm.nih.gov/pubmed/35105948
http://dx.doi.org/10.1038/s41434-022-00313-w

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