Cargando…

Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes

Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains incompletely understood. This study presents an in-dept characterization of aortic aging in male C57Bl/6 mice (2–24 months). Cardiovascular measurements include echocardiography, blood pressure measurement, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Moudt, Sofie, Hendrickx, Jhana O., Neutel, Cédric, De Munck, Dorien, Leloup, Arthur, De Meyer, Guido R. Y., Martinet, Wim, Fransen, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203497/ https://www.ncbi.nlm.nih.gov/pubmed/35710942 http://dx.doi.org/10.1038/s42003-022-03563-x

Ejemplares similares

Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction
por: De Moudt, Sofie, et al.
Publicado: (2022)

Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age
por: De Moudt, Sofie, et al.
Publicado: (2022)

Disparate biomechanical properties of the aorta in non‐aneurysmal and aneurysmal mice treated with angiotensin II
por: De Moudt, Sofie, et al.
Publicado: (2022)

Aortic Stiffness Hysteresis in Isolated Mouse Aortic Segments Is Intensified by Contractile Stimuli, Attenuated by Age, and Reversed by Elastin Degradation
por: De Moudt, Sofie, et al.
Publicado: (2021)

Defective Autophagy in Vascular Smooth Muscle Cells Alters Vascular Reactivity of the Mouse Femoral Artery
por: De Munck, Dorien G., et al.
Publicado: (2020)

Long-Term Pharmacological Inhibition of the Activity of All NOS Isoforms Rather Than Genetic Knock-Out of Endothelial NOS Leads to Impaired Spatial Learning and Memory in C57BL/6 Mice
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

The Protective Effects of the Autophagic and Lysosomal Machinery in Vascular and Valvular Calcification: A Systematic Review
por: Neutel, Cédric H. G., et al.
Publicado: (2020)

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

Increasing pulse pressure ex vivo, mimicking acute physical exercise, induces smooth muscle cell-mediated de-stiffening of murine aortic segments
por: Neutel, Cédric H. G., et al.
Publicado: (2023)

Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

High Pulsatile Load Decreases Arterial Stiffness: An ex vivo Study
por: Neutel, Cédric H. G., et al.
Publicado: (2021)

Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments
por: De Moudt, Sofie, et al.
Publicado: (2017)

Cyclic Stretch Alters Vascular Reactivity of Mouse Aortic Segments
por: Leloup, Arthur, et al.
Publicado: (2017)

Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy
por: Hendrickx, Jhana O., et al.
Publicado: (2022)

Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance
por: Leloup, Arthur J. A., et al.
Publicado: (2019)

Lung stiffness of C57BL/6 versus BALB/c mice
por: Rojas-Ruiz, Andrés, et al.
Publicado: (2023)

Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function
por: Craps, Sander, et al.
Publicado: (2021)

Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2022)

Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiovascular Remodelling in a Mouse Model of Advanced Atherosclerosis
por: Roth, Lynn, et al.
Publicado: (2021)

Dissecting out the Complex Ca(2+)-Mediated Phenylephrine-Induced Contractions of Mouse Aortic Segments
por: Fransen, Paul, et al.
Publicado: (2015)

The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion
por: Neutel, Cédric H. G., et al.
Publicado: (2023)

C57BL/6 life span study: age-related declines in muscle power production and contractile velocity
por: Graber, Ted G., et al.
Publicado: (2015)

Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice
por: DeWitt, Jamie C., et al.
Publicado: (2008)

Short-Term Angiotensin II Treatment Affects Large Artery Biomechanics and Function in the Absence of Small Artery Alterations in Mice
por: Leloup, Arthur J. A., et al.
Publicado: (2018)

Claudin-3-deficient C57BL/6J mice display intact brain barriers
por: Castro Dias, Mariana, et al.
Publicado: (2019)

Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta
por: Fransen, Paul, et al.
Publicado: (2012)

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice
por: Lim, Jana P, et al.
Publicado: (2012)

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice
por: Puylaert, Pauline, et al.
Publicado: (2022)

Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access
por: Capri, Kimberly M., et al.
Publicado: (2019)

Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers
por: Dias, Mariana Castro, et al.
Publicado: (2019)

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
por: Simon, Michelle M, et al.
Publicado: (2013)

Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation
por: Shindo, Miyuki, et al.
Publicado: (2021)

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach
por: Puylaert, Pauline, et al.
Publicado: (2022)

Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness
por: Gultian, Kirstene A., et al.
Publicado: (2022)

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
por: Fergusson, Grace, et al.
Publicado: (2014)

Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains
por: Nemoto, Shino, et al.
Publicado: (2022)

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
por: Wang, Tianhong, et al.
Publicado: (2017)

Experimental Hyalohyphomycosis by Purpureocillium lilacinum: Outcome of the Infection in C57BL/6 Murine Models
por: de Sequeira, Danielly C. M., et al.
Publicado: (2017)

A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice
por: Fisher-Wellman, Kelsey H., et al.
Publicado: (2016)

Copy number evolution in simple and complex tandem repeats across the C57BL/6 and C57BL/10 inbred mouse lines
por: Flynn, Jullien M, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ntmicka1afu4051iv6ik3okj0d