Capturing additional genetic risk from family history for improved polygenic risk prediction

Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle factors, as well as a common genetic predisposition. We developed a latent factor model to quantify trait heritability in excess of that captured by a com...

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Detalles Bibliográficos
Autores principales: Lu, Tianyuan, Forgetta, Vincenzo, Richards, J. Brent, Greenwood, Celia M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203758/
https://www.ncbi.nlm.nih.gov/pubmed/35710731
http://dx.doi.org/10.1038/s42003-022-03532-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203758/
https://www.ncbi.nlm.nih.gov/pubmed/35710731
http://dx.doi.org/10.1038/s42003-022-03532-4

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