Hyaluronidase 1 deficiency decreases bone mineral density in mice

Mucopolysaccharidosis IX is a lysosomal storage disorder caused by a deficiency in HYAL1, an enzyme that degrades hyaluronic acid at acidic pH. This disease causes juvenile arthritis in humans and osteoarthritis in the Hyal1 knockout mouse model. Our past research revealed that HYAL1 is strikingly u...

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Detalles Bibliográficos
Autores principales: Puissant, Emeline, Gilis, Florentine, Tevel, Virginie, Vandeweerd, Jean-Michel, Flamion, Bruno, Jadot, Michel, Boonen, Marielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203814/
https://www.ncbi.nlm.nih.gov/pubmed/35710820
http://dx.doi.org/10.1038/s41598-022-14473-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203814/
https://www.ncbi.nlm.nih.gov/pubmed/35710820
http://dx.doi.org/10.1038/s41598-022-14473-7

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