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Hyaluronidase 1 deficiency decreases bone mineral density in mice
Mucopolysaccharidosis IX is a lysosomal storage disorder caused by a deficiency in HYAL1, an enzyme that degrades hyaluronic acid at acidic pH. This disease causes juvenile arthritis in humans and osteoarthritis in the Hyal1 knockout mouse model. Our past research revealed that HYAL1 is strikingly u...
Autores principales: | Puissant, Emeline, Gilis, Florentine, Tevel, Virginie, Vandeweerd, Jean-Michel, Flamion, Bruno, Jadot, Michel, Boonen, Marielle |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203814/ https://www.ncbi.nlm.nih.gov/pubmed/35710820 http://dx.doi.org/10.1038/s41598-022-14473-7 |
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