Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer

Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARα activity in the liver. Restoring hepatic PPARα activity with fenofibrate increased circulating ketones and...

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Detalles Bibliográficos
Autores principales: Langer, Henning Tim, Ramsamooj, Shakti, Liang, Roger J., Grover, Rahul, Hwang, Seo-Kyoung, Goncalves, Marcus DaSilva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203842/
https://www.ncbi.nlm.nih.gov/pubmed/35719965
http://dx.doi.org/10.3389/fonc.2022.903157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203842/
https://www.ncbi.nlm.nih.gov/pubmed/35719965
http://dx.doi.org/10.3389/fonc.2022.903157

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