Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies (GWAS) have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory ele...

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Detalles Bibliográficos
Autores principales: Turner, Adam W., Hu, Shengen Shawn, Mosquera, Jose Verdezoto, Ma, Wei Feng, Hodonsky, Chani J., Wong, Doris, Auguste, Gaëlle, Song, Yipei, Sol-Church, Katia, Farber, Emily, Kundu, Soumya, Kundaje, Anshul, Lopez, Nicolas G., Ma, Lijiang, Ghosh, Saikat Kumar B., Onengut-Gumuscu, Suna, Ashley, Euan A., Quertermous, Thomas, Finn, Aloke V., Leeper, Nicholas J., Kovacic, Jason C., Björkgren, Johan L.M., Zang, Chongzhi, Miller, Clint L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203933/
https://www.ncbi.nlm.nih.gov/pubmed/35590109
http://dx.doi.org/10.1038/s41588-022-01069-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203933/
https://www.ncbi.nlm.nih.gov/pubmed/35590109
http://dx.doi.org/10.1038/s41588-022-01069-0

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