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Maternal Factor Dppa3 Activates 2C-Like Genes and Depresses DNA Methylation in Mouse Embryonic Stem Cells

Mouse embryonic stem cells (ESCs) contain a rare cell population of “two-cell embryonic like” cells (2CLCs) that display similar features to those found in the two-cell (2C) embryo and thus represent an in vitro model for studying the progress of zygotic genome activation (ZGA). However, the positiv...

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Detalles Bibliográficos
Autores principales: Zhang, Chuanyu, Wen, Hang, Liu, Siying, Fu, Enze, Yu, Lu, Chen, Shang, Han, Qingsheng, Li, Zongjin, Liu, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203971/
https://www.ncbi.nlm.nih.gov/pubmed/35721479
http://dx.doi.org/10.3389/fcell.2022.882671