Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to sickle cell disease (SCD) and β-thalassemia. Here, we identify via a CRISPR-Cas9 genetic screen tw...

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Detalles Bibliográficos
Autores principales: Qin, Kunhua, Huang, Peng, Feng, Ruopeng, Keller, Cheryl A., Peslak, Scott A., Khandros, Eugene, Saari, Megan, Lan, Xianjiang, Mayuranathan, Thiyagaraj, Doerfler, Phillip A., Abdulmalik, Osheiza, Giardine, Belinda, Chou, Stella T., Shi, Junwei, Hardison, Ross C., Weiss, Mitchell J., Blobel, Gerd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203980/
https://www.ncbi.nlm.nih.gov/pubmed/35618846
http://dx.doi.org/10.1038/s41588-022-01076-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203980/
https://www.ncbi.nlm.nih.gov/pubmed/35618846
http://dx.doi.org/10.1038/s41588-022-01076-1

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