Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs

Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to some extent from conventional two-chain Fv fra...

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Detalles Bibliográficos
Autores principales: Gaudreault, Francis, Corbeil, Christopher R., Purisima, Enrico O., Sulea, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203998/
https://www.ncbi.nlm.nih.gov/pubmed/35720356
http://dx.doi.org/10.3389/fimmu.2022.884132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203998/
https://www.ncbi.nlm.nih.gov/pubmed/35720356
http://dx.doi.org/10.3389/fimmu.2022.884132

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