PBRM1 Deficiency Sensitizes Renal Cancer Cells to DNMT Inhibitor 5-Fluoro-2’-Deoxycytidine

PBRM1 is a tumor suppressor frequently mutated in clear cell renal cell carcinoma. However, no effective targeted therapies exist for ccRCC with PBRM1 loss. To identify novel therapeutic approaches to targeting PBRM1-deficient renal cancers, we employed a synthetic lethality compound screening in is...

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Detalles Bibliográficos
Autores principales: Gu, Di, Dong, Kai, Jiang, Aimin, Jiang, Shaoqin, Fu, Zhibin, Bao, Yewei, Huang, Fuzhao, Yang, Chenghua, Wang, Linhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204009/
https://www.ncbi.nlm.nih.gov/pubmed/35719970
http://dx.doi.org/10.3389/fonc.2022.870229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204009/
https://www.ncbi.nlm.nih.gov/pubmed/35719970
http://dx.doi.org/10.3389/fonc.2022.870229

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