Cargando…

AhR Activation Leads to Attenuation of Murine Autoimmune Hepatitis: Single-Cell RNA-Seq Analysis Reveals Unique Immune Cell Phenotypes and Gene Expression Changes in the Liver

The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated transcription factor. While initially identified as an environmental sensor, this receptor has been shown more recently to regulate a variety of immune functions. AhR ligands vary in structure and source from environmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cannon, Alkeiver S., Holloman, Bryan Latrell, Wilson, Kiesha, Miranda, Kathryn, Dopkins, Nicholas, Nagarkatti, Prakash, Nagarkatti, Mitzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204231/ https://www.ncbi.nlm.nih.gov/pubmed/35720411 http://dx.doi.org/10.3389/fimmu.2022.899609

Ejemplares similares

Aryl Hydrocarbon Receptor Activation Ameliorates Acute Respiratory Distress Syndrome through Regulation of Th17 and Th22 Cells in the Lungs
por: Holloman, Bryan Latrell, et al.
Publicado: (2023)

Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases
por: Cannon, Alkeiver S., et al.
Publicado: (2021)

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases
por: Holloman, Bryan Latrell, et al.
Publicado: (2021)

From Suppressor T Cells to Regulatory T Cells: How the Journey that Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation
por: Prasad Singh, Narendra, et al.
Publicado: (2020)

AhR Activation Leads to Alterations in the Gut Microbiome with Consequent Effect on Induction of Myeloid Derived Suppressor Cells in a CXCR2-Dependent Manner
por: Neamah, Wurood Hantoosh, et al.
Publicado: (2020)

The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota
por: Abdulla, Osama A., et al.
Publicado: (2021)

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis
por: Singh, Narendra P., et al.
Publicado: (2011)

AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response
por: Abdulla, Osama A., et al.
Publicado: (2021)

Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor
por: Dopkins, Nicholas, et al.
Publicado: (2021)

AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA
por: Al-Ghezi, Zinah Zamil, et al.
Publicado: (2019)

Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol
por: Hegde, Venkatesh L., et al.
Publicado: (2011)

miR-466a Targeting of TGF-β2 Contributes to FoxP3(+) Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation
por: Becker, William, et al.
Publicado: (2018)

Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity
por: Miranda, Kathryn, et al.
Publicado: (2022)

Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis
por: Yang, Xiaoming, et al.
Publicado: (2019)

Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
por: Elliott, David M., et al.
Publicado: (2018)

Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions
por: Neamah, Wurood Hantoosh, et al.
Publicado: (2023)

Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production
por: Becker, William, et al.
Publicado: (2020)

Resveratrol attenuates staphylococcal enterotoxin B-activated immune cell metabolism via upregulation of miR-100 and suppression of mTOR signaling pathway
por: Alghetaa, Hasan, et al.
Publicado: (2023)

Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease-2019
por: Nagarkatti, Prakash, et al.
Publicado: (2020)

Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression
por: Mohammed, Amira, et al.
Publicado: (2020)

Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
por: Miranda, Kathryn, et al.
Publicado: (2019)

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands
por: Wisniewski, Paul J., et al.
Publicado: (2021)

Anandamide Attenuates Th-17 Cell-Mediated Delayed-Type Hypersensitivity Response by Triggering IL-10 Production and Consequent microRNA Induction
por: Jackson, Austin R., et al.
Publicado: (2014)

Effects of Acute 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure on the Circulating and Cecal Metabolome Profile
por: Dopkins, Nicholas, et al.
Publicado: (2021)

Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
por: Alharris, Esraah, et al.
Publicado: (2019)

Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways
por: Al-Ghezi, Zinah Zamil, et al.
Publicado: (2019)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
por: Gargaro, Marco, et al.
Publicado: (2021)

Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2016)

Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis
por: Busbee, Philip B., et al.
Publicado: (2015)

Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation
por: Varsha, Kontham Kulangara, et al.
Publicado: (2022)

Resveratrol Prevents Endothelial Cells Injury in High-Dose Interleukin-2 Therapy against Melanoma
por: Guan, Hongbing, et al.
Publicado: (2012)

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis
por: Sultan, Muthanna, et al.
Publicado: (2021)

Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2019)

Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2018)

MicroRNA-30 modulates metabolic inflammation by regulating notch signaling in adipose tissue macrophages
por: Miranda, Kathryn, et al.
Publicado: (2018)

AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity
por: Bourner, Luke A., et al.
Publicado: (2022)

The role of gut microbiota in shaping the relapse-remitting and chronic-progressive forms of multiple sclerosis in mouse models
por: Gandy, K. Alexa Orr, et al.
Publicado: (2019)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
por: Nguyen, Phuc-Tan, et al.
Publicado: (2023)

Induction of CD4(+)CD25(+) Regulatory T Cells from In Vitro Grown Human Mononuclear Cells by Sparteine Sulfate and Harpagoside
por: Atwany, Nour Z., et al.
Publicado: (2020)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a6711jnlhdvj3akscp4so9gknj