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Targeted Screening for Alzheimer's Disease Clinical Trials Using Data-Driven Disease Progression Models

Heterogeneity in Alzheimer's disease progression contributes to the ongoing failure to demonstrate efficacy of putative disease-modifying therapeutics that have been trialed over the past two decades. Any treatment effect present in a subgroup of trial participants (responders) can be diluted b...

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Detalles Bibliográficos
Autores principales: Oxtoby, Neil P., Shand, Cameron, Cash, David M., Alexander, Daniel C., Barkhof, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204250/
https://www.ncbi.nlm.nih.gov/pubmed/35719690
http://dx.doi.org/10.3389/frai.2022.660581