Cargando…

SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma

BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays a pivotal role in the development and progression of several cancer types in humans. However, the function and underlying mechanism o...

Descripción completa

Detalles Bibliográficos
Autores principales:	You, Weiqiang, Ke, Jia, Chen, Yufeng, Cai, Zerong, Huang, Ze-ping, Hu, Peishan, Wu, Xiaojian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204319/ https://www.ncbi.nlm.nih.gov/pubmed/35720314 http://dx.doi.org/10.3389/fimmu.2022.864244

Ejemplares similares

Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination
por: You, Weiqiang, et al.
Publicado: (2022)

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE
por: Yang, Fan, et al.
Publicado: (2021)

SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis
por: Wang, Shuhui, et al.
Publicado: (2022)

Corrigendum: MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE
por: Yang, Fan, et al.
Publicado: (2021)

Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis
por: Qian, Cui-juan, et al.
Publicado: (2023)

The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway
por: Li, Zhiqi, et al.
Publicado: (2023)

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma
por: Schmiechen, Zoe C., et al.
Publicado: (2021)

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
por: Kalogirou, C., et al.
Publicado: (2021)

Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy
por: Li, Ruiyu, et al.
Publicado: (2021)

Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma
por: Zhang, Yalu, et al.
Publicado: (2022)

S100A2 Is a Prognostic Biomarker Involved in Immune Infiltration and Predict Immunotherapy Response in Pancreatic Cancer
por: Chen, Yuan, et al.
Publicado: (2021)

Prognostic Stratification Based on HIF-1 Signaling for Evaluating Hypoxic Status and Immune Infiltration in Pancreatic Ductal Adenocarcinomas
por: Zhuang, Hongkai, et al.
Publicado: (2021)

The future of combination immunotherapy in oesophageal adenocarcinoma
por: Davern, Maria, et al.
Publicado: (2023)

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma
por: Li, Jing, et al.
Publicado: (2022)

Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes
por: Kim, Samuel I., et al.
Publicado: (2021)

Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy
por: Zhao, Zi-Yue, et al.
Publicado: (2022)

PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis
por: Kuang, Wenbin, et al.
Publicado: (2022)

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)
por: Hosen, S. M. Zahid, et al.
Publicado: (2022)

Identification of immune activation-related gene signature for predicting prognosis and immunotherapy efficacy in lung adenocarcinoma
por: Zeng, Weibiao, et al.
Publicado: (2023)

Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy
por: Bai, Ziyi, et al.
Publicado: (2022)

Characterization of Different Subtypes of Immune Cell Infiltration in Glioblastoma to Aid Immunotherapy
por: Feng, Peng, et al.
Publicado: (2022)

Model for predicting immunotherapy based on M2 macrophage infiltration in TNBC
por: Wu, Haoming, et al.
Publicado: (2023)

Tumor-infiltrating CCR2(+) inflammatory monocytes counteract specific immunotherapy
por: Bartneck, Joschka, et al.
Publicado: (2023)

Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes
por: He, Yi, et al.
Publicado: (2022)

SQLE Mediates Metabolic Reprogramming to Promote LN Metastasis in Castration-Resistant Prostate Cancer
por: Xu, Zhenzhou, et al.
Publicado: (2021)

Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma
por: Luan, Hong, et al.
Publicado: (2020)

Non-coding RNA in tumor-infiltrating regulatory T cells formation and associated immunotherapy
por: Ma, Yue, et al.
Publicado: (2023)

SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma
por: OuYang, Li-Ying, et al.
Publicado: (2022)

Comprehensive analysis of anoikis-related long non-coding RNA immune infiltration in patients with bladder cancer and immunotherapy
por: Zhang, Yao-Yu, et al.
Publicado: (2022)

B-Lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma
por: Minici, Claudia, et al.
Publicado: (2022)

Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer
por: Luo, Zhi-Wen, et al.
Publicado: (2023)

Characterization of m(6)A RNA Methylation Regulators Predicts Survival and Immunotherapy in Lung Adenocarcinoma
por: Zhu, Minggao, et al.
Publicado: (2021)

A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis
por: Qin, Yilu, et al.
Publicado: (2020)

A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis
por: Qin, Yilu, et al.
Publicado: (2022)

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
por: Mahoney, Christopher E., et al.
Publicado: (2019)

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene
por: Taghipour, Simin, et al.
Publicado: (2020)

Novel Insight into the Role of Squalene Epoxidase (SQLE) Gene in Determining Milk Production Traits in Buffalo
por: Chen, Chao, et al.
Publicado: (2023)

Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy
por: van Pul, Kim M., et al.
Publicado: (2021)

Estrogen-related genes influence immune cell infiltration and immunotherapy response in Hepatocellular Carcinoma
por: Gao, Biao, et al.
Publicado: (2023)

Identification of calcium and integrin-binding protein 1 as a reprogrammed glucose metabolism mediator to restrict immune cell infiltration in the stromal compartment of pancreatic ductal adenocarcinoma
por: Ma, Junrui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3q1jsd27p5eki3mm6mg54dmdvm