Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water

[Image: see text] The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding the emergence of life. Building on our recent discovery that thiols catalyze the ligation of amino acids, amides, and peptides with amidonitriles in neutral water, we demonstrate the outco...

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Detalles Bibliográficos
Autores principales: Singh, Jyoti, Whitaker, Daniel, Thoma, Benjamin, Islam, Saidul, Foden, Callum S., Aliev, Abil E., Sheppard, Tom D., Powner, Matthew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204760/
https://www.ncbi.nlm.nih.gov/pubmed/35640067
http://dx.doi.org/10.1021/jacs.2c03486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204760/
https://www.ncbi.nlm.nih.gov/pubmed/35640067
http://dx.doi.org/10.1021/jacs.2c03486

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